BIOphysics & SOFT Matter Department of Ultrafast Optics and Nanophotonics

Institut de Physique et Chimie des Matériaux de Strasbourg

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Mechanical phenotype

Wilfried Grange, Pascal Hébraud

The mechanical properties of cells play a key role in regulating a large number of physiological functions. For instance, a change in mobility would allow a single cell to detach from a primary tumor site, infiltrate adjacent tissues, penetrate the vascular walls and finally colonize competent organs. To study the mechanical phenotype of cells, we use a technique kwnon as Traction Force Microscopy and aim at correlating the change in the mechanical properties and the onset of a metastatic phenotype (Movie. scale bar: 0.01 mm).

Further Reading
Makarchuk, Stanislaw; Beyer, Nicolas; Gaiddon, Christian; Grange, Wilfried and Hébraud, Pascal. Holographic Traction Force Microscopy. Scientific Reports, 8, 2018